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Clinical microbiology and vaccines

This section aims to publish studies looking at all aspects of clinical microbiology, including virology, epidemiology, antimicrobial resistance, vaccines and immune responses.

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  1. Urinary tract infection (UTI) is one of the most common diagnoses in girls and women, and to a lesser extent in boys and men younger than 50 years. Escherichia coli, followed by Klebsiella spp. and Proteus spp., ...

    Authors: Milena Lussu, Tania Camboni, Cristina Piras, Corrado Serra, Francesco Del Carratore, Julian Griffin, Luigi Atzori and Aldo Manzin

    Citation: BMC Microbiology 2017 17:201

    Content type: Methodology Article

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  2. Citrobacter strains are opportunistic pathogens often responsible for serious enteric as well as extra-intestinal diseases, and therefore the O-antigenic scheme, still in use in diagno...

    Authors: Ewa Katzenellenbogen, Magdalena Staniszewska, Nina A. Kocharova, Małgorzata Mieszała, Agnieszka Korzeniowska-Kowal, Sabina Górska, Yuriy A. Knirel and Andrzej Gamian

    Citation: BMC Microbiology 2017 17:169

    Content type: Research article

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    The Erratum to this article has been published in BMC Microbiology 2017 17:173

  3. Cationic antibacterial peptides (CAPs) and synthetic molecules mimicking the amphiphilic structure of CAPs, such as ceragenins, are promising compounds for the development of new antimicrobials.

    Authors: Bonita Durnaś, Ewelina Piktel, Marzena Wątek, Tomasz Wollny, Stanisław Góźdź, Jolanta Smok-Kalwat, Katarzyna Niemirowicz, Paul B. Savage and Robert Bucki

    Citation: BMC Microbiology 2017 17:167

    Content type: Research article

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  4. The ecological plaque hypothesis explains caries development as the result of the enrichment of acid tolerant bacteria in dental biofilms in response to prolonged periods of low pH. Acid production by an acid ...

    Authors: A Senneby, JR Davies, G Svensäter and J Neilands

    Citation: BMC Microbiology 2017 17:165

    Content type: Research article

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  5. Alphaviruses are arthropod borne RNA viruses of medical importance. Geographical expansion of mosquitoes of the Aedes genus in the past decades has been associated with major Alphavirus-associated outbreaks. Clim...

    Authors: Claude Giry, Bénédicte Roquebert, Ghislaine Li-Pat-Yuen, Philippe Gasque and Marie-Christine Jaffar-Bandjee

    Citation: BMC Microbiology 2017 17:164

    Content type: Methodology Article

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  6. MALDI-TOF MS is an analytical method that has recently become integral in the identification of microorganisms in clinical laboratories. It relies on databases that majorly employ pattern recognition or finger...

    Authors: Ali Kassim, Valentin Pflüger, Zul Premji, Claudia Daubenberger and Gunturu Revathi

    Citation: BMC Microbiology 2017 17:128

    Content type: Research article

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  7. Diagnosis of enterotoxigenic E. coli (ETEC) associated diarrhea is complicated by the diversity of E.coli virulence factors. This study developed a multiplex quantitative PCR assay based on high-resolution meltin...

    Authors: Weilan Wang, Ruurd T. Zijlstra and Michael G. Gänzle

    Citation: BMC Microbiology 2017 17:114

    Content type: Methodology Article

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  8. Acute gastroenteritis is a common cause of morbidity and mortality in humans worldwide. The rapid and specific identification of infectious agents is crucial for correct patient management. However, diagnosis ...

    Authors: Antonio Piralla, Giovanna Lunghi, Gianluigi Ardissino, Alessia Girello, Marta Premoli, Erika Bava, Milena Arghittu, Maria Rosaria Colombo, Alessandra Cognetto, Patrizia Bono, Giulia Campanini, Piero Marone and Fausto Baldanti

    Citation: BMC Microbiology 2017 17:111

    Content type: Research article

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  9. This study of the oropharyngeal microbiome complements the previously published AZIthromycin in Severe ASThma (AZISAST) clinical trial, where the use of azithromycin was assessed in subjects with exacerbation-...

    Authors: Guido Lopes dos Santos Santiago, Guy Brusselle, Kenny Dauwe, Pieter Deschaght, Chris Verhofstede, Dries Vaneechoutte, Ellen Deschepper, Paul Jordens, Guy Joos and Mario Vaneechoutte

    Citation: BMC Microbiology 2017 17:109

    Content type: Research article

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  10. In 2005–2006 a major epidemics of Chikungunya disease occurred in South-West Indian Ocean islands. In Reunion Island, the magnitude of Chikungunya infection related symptoms was high and with over 38% of serol...

    Authors: Claude Giry, Bénédicte Roquebert, Ghislaine Li-Pat-Yuen, Philippe Gasque and Marie-Christine Jaffar-Bandjee

    Citation: BMC Microbiology 2017 17:105

    Content type: Methodology Article

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  11. The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) isolated in horse infections is not well documented, especially in France. The aim of the study was to evaluate the prevalence of MRSA isolat...

    Authors: François Guérin, Marguerite Fines-Guyon, Pierrick Meignen, Géraldine Delente, Caroline Fondrinier, Nancy Bourdon, Vincent Cattoir and Albertine Léon

    Citation: BMC Microbiology 2017 17:104

    Content type: Researc article

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  12. Accurate identification of Aspergillus species is a very important subject. Mass spectral fingerprinting using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) is genera...

    Authors: Sayaka Nakamura, Hiroaki Sato, Reiko Tanaka, Yoko Kusuya, Hiroki Takahashi and Takashi Yaguchi

    Citation: BMC Microbiology 2017 17:100

    Content type: Methodology Article

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  13. Campylobacteriosis is a dominant bacterial cause of foodborne infection and is considered the main public health problem in Europe and many other countries worldwide. In the study lasting from 2011 to 2013 we ...

    Authors: Bernadeta Szczepanska, Małgorzata Andrzejewska, Dorota Spica and Jacek J. Klawe

    Citation: BMC Microbiology 2017 17:80

    Content type: Research article

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  14. Sample collection for gut microbiota analysis from in-patients can be challenging. Collection method and storage conditions are potential sources of variability. In this study, we compared the bacterial microb...

    Authors: Christine M. Bassis, Nicholas M. Moore, Karen Lolans, Anna M. Seekatz, Robert A. Weinstein, Vincent B. Young and Mary K. Hayden

    Citation: BMC Microbiology 2017 17:78

    Content type: Methodology article

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  15. Mass drug administration (MDA) with azithromycin is a corner-stone of trachoma control however it may drive the emergence of antimicrobial resistance. In a cluster-randomized trial (Clinical trial gov NCT00792...

    Authors: Ebrima Bojang, James Jafali, Vincent Perreten, John Hart, Emma M. Harding-Esch, Ansumana Sillah, David C. W. Mabey, Martin J. Holland, Robin L. Bailey, Anna Roca and Sarah E. Burr

    Citation: BMC Microbiology 2017 17:75

    Content type: Research article

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  16. Carbapenems resistance in Enterobacter spp. has increased in the last decade, few studies, however, described the mechanisms of resistance in this bacterium. This study evaluated clonality and mechanisms of carba...

    Authors: Juliana Ferraz Rosa, Camila Rizek, Ana Paula Marchi, Thais Guimaraes, Lourdes Miranda, Claudia Carrilho, Anna S Levin and Silvia F Costa

    Citation: BMC Microbiology 2017 17:69

    Content type: Research article

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  17. After E. coli O157, E. coli O26 is the second most prevalent enterohaemorrhagic E. coli (EHEC) serotype identified in cases of foodborne illness in Australia and throughout the world. E. coli O26 associated foodb...

    Authors: Salma A. Lajhar, Jeremy Brownlie and Robert Barlow

    Citation: BMC Microbiology 2017 17:47

    Content type: Research article

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  18. The meningococcal capsule is an important virulence determinant. Unencapsulated meningococci lacking capsule biosynthesis genes and containing the capsule null locus (cnl) are predominantly non-pathogenic. Rare c...

    Authors: Karistha Ganesh, Mushal Allam, Nicole Wolter, Holly B. Bratcher, Odile B. Harrison, Jay Lucidarme, Ray Borrow, Linda de Gouveia, Susan Meiring, Monica Birkhead, Martin C. J. Maiden, Anne von Gottberg and Mignon du Plessis

    Citation: BMC Microbiology 2017 17:40

    Content type: Research article

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  19. Pseudomonas aeruginosa typically displays loss of virulence-associated secretions over the course of chronic cystic fibrosis infections. This has led to the suggestion that virulence i...

    Authors: Siobhán O’Brien, David Williams, Joanne L. Fothergill, Steve Paterson, Craig Winstanley and Michael A. Brockhurst

    Citation: BMC Microbiology 2017 17:30

    Content type: Research article

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  20. The bronchial microbiome in chronic lung diseases presents an abnormal pattern, but its microbial composition and regional differences in severe asthma have not been sufficiently addressed. The aim of the stud...

    Authors: Laura Millares, Guadalupe Bermudo, Vicente Pérez-Brocal, Christian Domingo, Marian Garcia-Nuñez, Xavier Pomares, Andrés Moya and Eduard Monsó

    Citation: BMC Microbiology 2017 17:20

    Content type: Research article

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  21. Bovine enterovirus (BEV) belongs to the species Enterovirus E or F, genus Enterovirus and family Picornaviridae. Although numerous studies have identified BEVs in the feces of cattle with diarrhea, the pathogenic...

    Authors: Shinobu Tsuchiaka, Sayed Samim Rahpaya, Konosuke Otomaru, Hiroshi Aoki, Mai Kishimoto, Yuki Naoi, Tsutomu Omatsu, Kaori Sano, Sachiko Okazaki-Terashima, Yukie Katayama, Mami Oba, Makoto Nagai and Tetsuya Mizutani

    Citation: BMC Microbiology 2017 17:18

    Content type: Research article

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  22. Ticks transmit Babesia microti, the causative agents of babesiosis in North America and Europe. Babesiosis is now endemic in Northeastern USA and affects people of all ages. Babesia species infect erythrocytes an...

    Authors: Lavoisier Akoolo, Samantha Schlachter, Rasel Khan, Laura Alter, Albert D. Rojtman, Kristine Gedroic, Purnima Bhanot and Nikhat Parveen

    Citation: BMC Microbiology 2017 17:16

    Content type: Researc article

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  23. Staphylococcus epidermidis is an opportunistic pathogen involved in hospital-acquired infections, particularly in those related to medical devices. This study characterized 50 genetica...

    Authors: Vivian Carolina Salgueiro, Natalia Lopes Pontes Iorio, Marcelle Cristina Ferreira, Raiane Cardoso Chamon and Kátia Regina Netto dos Santos

    Citation: BMC Microbiology 2017 17:15

    Content type: Research article

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  24. Scrub typhus is a mite-borne rickettsiosis caused by infection of Orientia tsutsugamushi, which is endemic to several Asia-Pacific Rim countries, including Japan. Although micro-indirect immunofluorescent assay (...

    Authors: Motohiko Ogawa, Masaaki Satoh, Masayuki Saijo and Shuji Ando

    Citation: BMC Microbiology 2017 17:7

    Content type: Methodology article

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  25. The prevalence of Helicobacter pylori antibiotic susceptibility in the Nepalese strains is untracked. We determined the antibiotic susceptibility for H. pylori and analyzed the presence of genetic mutations assoc...

    Authors: Muhammad Miftahussurur, Pradeep Krishna Shrestha, Phawinee Subsomwong, Rabi Prakash Sharma and Yoshio Yamaoka

    Citation: BMC Microbiology 2016 16:256

    Content type: Research article

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  26. Quinupristin/dalfopristin (Q/D) is a valuable alternative antibiotic to vancomycin for the treatment of multi-drug resistant Enterococcus faecium infections. However, resistance to Q/D in E. faecium clinical isol...

    Authors: Shanshan Wang, Yinjuan Guo, Jingnan Lv, Xiuqin Qi, Dan Li, Zengqiang Chen, Xueqing Zhang, Liangxing Wang and Fangyou Yu

    Citation: BMC Microbiology 2016 16:246

    Content type: Research article

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  27. Leptospirosis is an important reemerging zoonosis, with more than half a million cases reported annually, and is caused by pathogenic Leptospira species. Development of a universal vaccine is one of the major str...

    Authors: Xu’ai Lin, Guohui Xiao, Dongjiao Luo, Liangliang Kong, Xu Chen, Dexter Sun and Jie Yan

    Citation: BMC Microbiology 2016 16:241

    Content type: Research article

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  28. Increasing age, several co-morbidities, environmental contamination, antibiotic exposure and other intestinal perturbations appear to be the greatest risk factors for C. difficile infection (CDI). Therefore, elde...

    Authors: Cristina Rodriguez, Bernard Taminiau, Nicolas Korsak, Véronique Avesani, Johan Van Broeck, Philippe Brach, Michel Delmée and Georges Daube

    Citation: BMC Microbiology 2016 16:229

    Content type: Research article

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  29. Pneumococcal adherence to the nasopharyngeal epithelium is a critical step in colonisation and disease. The probiotic bacterium, Streptococcus salivarius, can inhibit pneumococcal adherence to epithelial cells in...

    Authors: Jayne Manning, Eileen M. Dunne, Philip A. Wescombe, John D. F. Hale, E. Kim Mulholland, John R. Tagg, Roy M. Robins-Browne and Catherine Satzke

    Citation: BMC Microbiology 2016 16:225

    Content type: Research article

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  30. Despite the high prevalence of genotype 1b hepatitis C virus (HCV) among patients, a cell culture system that permits entire viral life cycle of genotype 1b isolates is limited. To develop a cell-cultured hepa...

    Authors: Ken-ichi Mori, Akihiro Matsumoto, Noboru Maki, Yuki Ichikawa, Eiji Tanaka and Shintaro Yagi

    Citation: BMC Microbiology 2016 16:224

    Content type: Research article

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  31. Despite the implementation of prevention guidelines, group B Streptococcal (GBS) infection remains a leading cause of sepsis, pneumonia, and meningitis, resulting in significant neonatal morbidity and mortalit...

    Authors: Christina Clarke, Louise O’Connor, Heather Carré-Skinner, Olaf Piepenburg and Terry J. Smith

    Citation: BMC Microbiology 2016 16:221

    Content type: Research article

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  32. Organoselenium compounds have antimicrobial activity against some bacteria and fungi; furthermore, the antioxidant activity of diselenides has been demonstrated. The aim of the present work was to examine the ...

    Authors: Luca Sancineto, Miranda Piccioni, Stefania De Marco, Rita Pagiotti, Vanessa Nascimento, Antonio Luiz Braga, Claudio Santi and Donatella Pietrella

    Citation: BMC Microbiology 2016 16:220

    Content type: Research article

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  33. Gonorrhoea is a sexually transmitted infection caused by the Gram-negative bacterium Neisseria gonorrhoeae. Resistance to first-line empirical monotherapy has emerged, so robust methods are needed to evaluate the...

    Authors: Sunniva Foerster, Magnus Unemo, Lucy J. Hathaway, Nicola Low and Christian L. Althaus

    Citation: BMC Microbiology 2016 16:216

    Content type: Methodology article

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  34. Chlorhexidine (CHX) is used in oral care products to help control dental plaque. In this study dental plaque bacteria were grown on media containing 2 μg/ml chlorhexidine gluconate to screen for bacteria with ...

    Authors: Hafiz Ghulam Murtaza Saleem, Christine Ann Seers, Anjum Nasim Sabri and Eric Charles Reynolds

    Citation: BMC Microbiology 2016 16:214

    Content type: Research article

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  35. Globally, staphylococci have developed resistance to many antibiotics. New approaches to chemotherapy are needed and one such approach could be to use plant derived actives with conventional antibiotics in a s...

    Authors: Sineewan Phitaktim, Mullika Chomnawang, Kittipot Sirichaiwetchakoon, Benjawan Dunkhunthod, Glyn Hobbs and Griangsak Eumkeb

    Citation: BMC Microbiology 2016 16:195

    Content type: Research article

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  36. Domestic combustion of biomass fuels, such as wood, charcoal, crop residue and dung causes Household Air Pollution (HAP). These inhaled particulates affect more than half of the world’s population, causing res...

    Authors: Jamie Rylance, Anstead Kankwatira, David E. Nelson, Evelyn Toh, Richard B. Day, Huaiying Lin, Xiang Gao, Qunfeng Dong, Erica Sodergren, George M. Weinstock, Robert S Heyderman, Homer L. Twigg III and Stephen B. Gordon

    Citation: BMC Microbiology 2016 16:182

    Content type: Research article

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  37. Generation of extended- spectrum β- lactamases is one of the major mechanisms by which clinical Klebsiella pneumoniae develop resistance to antibiotics. Combined antibiotics prove to be a relatively effective met...

    Authors: Wenhui Cai, Yingmei Fu, Wenli Zhang, Xiaobei Chen, Jizi Zhao, Wuqi Song, Yujun Li, Ying Huang, Zheng Wu, Rui Sun, Chunping Dong and Fengmin Zhang

    Citation: BMC Microbiology 2016 16:181

    Content type: Research article

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  38. Enterotoxigenic E. coli (ETEC) significantly contribute to diarrhea in piglets and weaners. The smallholder pig producers in Uganda identified diarrhea as one of the major problems especially in piglets. The aim ...

    Authors: Kokas Ikwap, Jenny Larsson, Magdalena Jacobson, David Okello Owiny, George William Nasinyama, Immaculate Nabukenya, Sigbrit Mattsson, Anna Aspan and Joseph Erume

    Citation: BMC Microbiology 2016 16:178

    Content type: Research article

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  39. Chlamydia trachomatis is a human pathogen which causes a number of pathologies, including genital tract infections in women that can result in tubal infertility. Prevention of infectio...

    Authors: Zhiyun Wen, Melissa A. Boddicker, Robin M. Kaufhold, Puneet Khandelwal, Eberhard Durr, Ping Qiu, Bob J. Lucas, Debbie D. Nahas, James C. Cook, Sinoeun Touch, Julie M. Skinner, Amy S. Espeseth, Craig T. Przysiecki and Lan Zhang

    Citation: BMC Microbiology 2016 16:165

    Content type: Research article

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  40. The increasing emergence of drug-resistant tuberculosis presents a threat to the effective control of tuberculosis (TB). Rapid detection of drug-resistance is more important than ever to address this scourge. ...

    Authors: Joanna Spinato, Élyse Boivin, Émilie Bélanger-Trudelle, Huguette Fauchon, Cécile Tremblay and Hafid Soualhine

    Citation: BMC Microbiology 2016 16:164

    Content type: Research article

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  41. The E2 multimeric scaffold represents a powerful delivery system able to elicit robust humoral and cellular immune responses upon systemic administrations. Here recombinant E2 scaffold displaying the third var...

    Authors: Maria Trovato, Francesco Maurano, Luciana D’Apice, Valerio Costa, Rossella Sartorius, Fausta Cuccaro, Sean P. McBurney, Shelly J. Krebs, Antonella Prisco, Alfredo Ciccodicola, Mauro Rossi, Nancy L. Haigwood and Piergiuseppe De Berardinis

    Citation: BMC Microbiology 2016 16:152

    Content type: Research article

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  42. Probiotics have shown favourable properties in maintaining oral health. By interacting with oral microbial communities, these species could contribute to healthier microbial equilibrium. This study aimed to in...

    Authors: Qingru Jiang, Iva Stamatova, Veera Kainulainen, Riitta Korpela and Jukka H. Meurman

    Citation: BMC Microbiology 2016 16:149

    Content type: Research article

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  43. Pseudomonas aeruginosa is the predominant pathogen associated with the decline of pulmonary function in cystic fibrosis (CF) patients. Both environment-to-host acquisition and patient-...

    Authors: Cristina Cigana, Paola Melotti, Rossella Baldan, Elisa Pedretti, Emily Pintani, Patrizia Iansa, Ida De Fino, Flavio Favari, Gabriella Bergamini, Gloria Tridello, Daniela M. Cirillo, Baroukh M. Assael and Alessandra Bragonzi

    Citation: BMC Microbiology 2016 16:142

    Content type: Research article

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  44. Resistance amongst the commensal flora is a serious threat because a very highly populated ecosystem like the gut, may at a later stage, be a source of extra intestinal infections, resistant strains may spread...

    Authors: Gajanand Mittal, Rajni Gaind, Deepak Kumar, Gaurav Kaushik, Kunj Bihari Gupta, P. K. Verma and Monorama Deb

    Citation: BMC Microbiology 2016 16:138

    Content type: Research article

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  45. The Middle East is regarded as a secondary reservoir for OXA-48 and New Delhi metallo-β-lactamase (NDM) carbapenemases. One of the main challenges in clinical microbiology diagnostics is the detection of carba...

    Authors: Rasha Elsherif, Dalia Ismail, Sanaa Elawady, Samyah Jastaniah, Saad Al-Masaudi, Steve Harakeh and Gamal Karrouf

    Citation: BMC Microbiology 2016 16:135

    Content type: Research article

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  46. S. pneumoniae is the leading cause of acute bacterial meningitis (ABM) in children. Vaccination using the 10-valent conjugate vaccine (PCV-10) was recently introduced into the National...

    Authors: Aquino Albino Nhantumbo, Eduardo Samo Gudo, Juliana Caierão, Alcides Moniz Munguambe, Charlotte Elizabeth Comé, Tomás Francisco Zimba, Milton Ozório Moraes, Cícero Dias and Vlademir Vicente Cantarelli

    Citation: BMC Microbiology 2016 16:134

    Content type: Research article

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