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Clinical microbiology and vaccines

This section aims to publish studies looking at all aspects of clinical microbiology, including virology, epidemiology, antimicrobial resistance, vaccines and immune responses.

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  1. Broad-range fungal inter spacer region (ITS) polymerase chain reaction (PCR) has been evaluated for the detection and identification of fungi in clinical specimens from severely immunocompromised patients, but...

    Authors: Silvana K. Rampini, Andrea Zbinden, Roberto F. Speck and Guido V. Bloemberg

    Citation: BMC Microbiology 2016 16:132

    Content type: Research article

    Published on:

  2. More than 94 serotypes of Streptococcus pneumoniae have been described to date, however the majority of disease is caused by approximately 20 serotypes. Some pneumococci do not react with commercially available a...

    Authors: Kedibone M. Ndlangisa, Mignon du Plessis, Mushal Allam, Nicole Wolter, Thabo Mohale, Linda de Gouveia, Monica Birkhead, Keith P. Klugman and Anne von Gottberg

    Citation: BMC Microbiology 2016 16:126

    Content type: Research article

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  3. Infection caused by ureteral stent indwelling is one of the most difficult medical problems, since once bacteria reside in biofilms they are extremely resistant to antibiotics as well as to the host immune def...

    Authors: Xianfeng Wang, Yongqing Cai, Haiyan Xing, Wei Wu, Guanying Wang, Ling Li and Jianhong Chen

    Citation: BMC Microbiology 2016 16:124

    Content type: Research article

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  4. Giardia duodenalis is the etiologic agent of giardiasis in humans and other mammals worldwide. The burden of disease is high among children in developing countries where sanitation is ...

    Authors: Teklu Wegayehu, Md Robiul Karim, Junqiang Li, Haileeyesus Adamu, Berhanu Erko, Longxian Zhang and Getachew Tilahun

    Citation: BMC Microbiology 2016 16:89

    Content type: Research article

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  5. Group B Streptococcus (GBS) is a leading cause of sepsis and meningitis and an important factor in premature and stillbirths. Biofilm production has been suggested to be important for GBS pathogenesis alongside m...

    Authors: Robert E. Parker, Clare Laut, Jennifer A. Gaddy, Ruth N. Zadoks, H. Dele Davies and Shannon D. Manning

    Citation: BMC Microbiology 2016 16:86

    Content type: Research article

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  6. The Staphylococcus genus is composed of 44 species, with S. aureus being the most pathogenic. Isolates of S. aureus are generally susceptible to β-lactam antibiotics, but extensive use of this class of drugs has ...

    Authors: Nicholas R. Saichek, Christopher R. Cox, Seungki Kim, Peter B. Harrington, Nicholas R. Stambach and Kent J. Voorhees

    Citation: BMC Microbiology 2016 16:72

    Content type: Research article

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  7. Increased resistance to antimicrobial agents is a characteristic of many bacteria growing in biofilms on for example indwelling urinary catheters or in intracellular bacterial reservoirs. Biofilm-related infec...

    Authors: Charlotte Sahlberg Bang, Robert Kruse, Kjell Johansson and Katarina Persson

    Citation: BMC Microbiology 2016 16:64

    Content type: Research article

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  8. Escherichia coli is the most common cause of urinary tract infection (UTI). The pathogenic isolates are becoming increasingly resistant to antibiotics; with a worldwide dissemination o...

    Authors: Frederik Boëtius Hertz, Jesper Boye Nielsen, Kristian Schønning, Pia Littauer, Jenny Dahl Knudsen, Anders Løbner-Olesen and Niels Frimodt-Møller

    Citation: BMC Microbiology 2016 16:63

    Content type: Research article

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    The Erratum to this article has been published in BMC Microbiology 2016 16:114

  9. Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder of unclear etiopathogenesis. Although recent studies of the oral microbiota by high-throughput sequencing of 16S rRNA genes have suggested ...

    Authors: Yun-ji Kim, Yun Sik Choi, Keum Jin Baek, Seok-Hwan Yoon, Hee Kyung Park and Youngnim Choi

    Citation: BMC Microbiology 2016 16:57

    Content type: Research article

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  10. With the global efforts of reducing pneumococcal disease through widespread introduction of pneumococcal vaccines, concerns have emerged on the potential increase of morbidity and mortality from S. aureus disease...

    Authors: Chinelo Ebruke, Michel M. Dione, Brigitte Walter, Archibald Worwui, Richard A. Adegbola, Anna Roca and Martin Antonio

    Citation: BMC Microbiology 2016 16:38

    Content type: Research article

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  11. Penicillium marneffei is the most important thermal dimorphic fungus causing systemic mycosis in HIV-infected and other immunocompromised patients in Southeast Asia. However, laborator...

    Authors: Susanna K. P. Lau, Clare S. K. Lam, Antonio H. Y. Ngan, Wang-Ngai Chow, Alan K. L. Wu, Dominic N. C. Tsang, Cindy W. S. Tse, Tak-Lun Que, Bone S. F. Tang and Patrick C. Y. Woo

    Citation: BMC Microbiology 2016 16:36

    Content type: Research article

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  12. Salmonellae are major worldwide zoonotic pathogens infecting a wide range of vertebrate species including humans. Consumption of contaminated dairy products and contact with dairy catt...

    Authors: Tadesse Eguale, Ephrem Engidawork, Wondwossen A. Gebreyes, Daniel Asrat, Haile Alemayehu, Girmay Medhin, Roger P. Johnson and John S. Gunn

    Citation: BMC Microbiology 2016 16:20

    Content type: Research article

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  13. Nosocomial infections caused by the bacterial pathogen Staphylococcus aureus can lead to serious complications due to the varying presence of secreted toxins. Comparative studies of genomic information and produc...

    Authors: Andreas Roetzer, Guenter Haller, John Beyerly, Christoph B. Geier, Hermann M. Wolf, Corina S. Gruener, Nina Model and Martha M. Eibl

    Citation: BMC Microbiology 2016 16:13

    Content type: Research article

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  14. Dengue virus (DENV), the most widely prevalent arbovirus, continues to be a threat to human health in the tropics and subtropics. Early and rapid detection of DENV infection during the acute phase of illness i...

    Authors: Sheng-feng Hu, Miao Li, Lan-lan Zhong, Shi-miao Lu, Ze-xia Liu, Jie-ying Pu, Jin-sheng Wen and Xi Huang

    Citation: BMC Microbiology 2015 15:265

    Content type: Research article

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  15. Antibiotic resistance genes can be targeted by antisense agents, which can reduce their expression and thus restore cellular susceptibility to existing antibiotics. Antisense inhibitors can be gene and pathoge...

    Authors: Shan Goh, Anette Loeffler, David H. Lloyd, Sean P. Nair and Liam Good

    Citation: BMC Microbiology 2015 15:262

    Content type: Research article

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  16. Bloodstream infections represent serious conditions carrying a high mortality and morbidity rate. Rapid identification of microorganisms and prompt institution of adequate antimicrobial therapy is of utmost im...

    Authors: Aleksandra Jakovljev and Kåre Bergh

    Citation: BMC Microbiology 2015 15:258

    Content type: Research article

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  17. Antibiotics of the β-lactam group are able to alter the shape of the bacterial cell wall, e.g. filamentation or a spheroplast formation. Early determination of antimicrobial susceptibility may be complicated b...

    Authors: Marlene Fredborg, Flemming S. Rosenvinge, Erik Spillum, Stine Kroghsbo, Mikala Wang and Teis E. Sondergaard

    Citation: BMC Microbiology 2015 15:255

    Content type: Methodology article

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  18. The human pathogenic mold Aspergillus fumigatus is able to form a complex biofilm embedded in extracellular matrix. Biofilms confer antimicrobial resistance and it is well known that aspergillosis is often refrac...

    Authors: Federica Perdoni, Paola Signorelli, Daniela Cirasola, Anna Caretti, Valentina Galimberti, Marco Biggiogera, Paolo Gasco, Claudia Musicanti, Giulia Morace and Elisa Borghi

    Citation: BMC Microbiology 2015 15:248

    Content type: Research article

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  19. Despite widespread use, optimum choice of antimicrobial agents, concentrations, combinations and exposure times have not been determined for antibiotic lock technique (ALT). Our objective was to evaluate the e...

    Authors: Diego Parra, Alejandro Peña-Monje, Nieves María Coronado-Álvarez, José Hernández-Quero and Jorge Parra-Ruiz

    Citation: BMC Microbiology 2015 15:245

    Content type: Research article

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  20. Biosurfactants are surface-active biomolecules with great applicability in the food, pharmaceutical and oil industries. Endospore-forming bacteria, which survive for long periods in harsh environments, are des...

    Authors: Camila Rattes de Almeida Couto, Vanessa Marques Alvarez, Joana Montezano Marques, Diogo de Azevedo Jurelevicius and Lucy Seldin

    Citation: BMC Microbiology 2015 15:240

    Content type: Research article

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  21. International travel contributes to the spread of antibiotic resistant bacteria over the world. Most studies addressing travel-related changes in the faecal flora have focused on specific mobile resistance gen...

    Authors: Anna Johnning, Erik Kristiansson, Martin Angelin, Nachiket Marathe, Yogesh S. Shouche, Anders Johansson and D. G. Joakim Larsson

    Citation: BMC Microbiology 2015 15:235

    Content type: Research article

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  22. Efflux has been recognized as a resistance mechanism to antimicrobials in Staphylococcus aureus; however its role on the development of clinically relevant resistance is still poorly characterized. This study aim...

    Authors: Sofia Santos Costa, Miguel Viveiros, Adriana E. Rosato, José Melo-Cristino and Isabel Couto

    Citation: BMC Microbiology 2015 15:232

    Content type: Research article

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  23. Xpert MTB/RIF assay is considered as a great advance over conventional smear and culture in the diagnosis of TB and MDR-TB by simultaneously detecting M.tuberculosis and rifampicin resistance bacilli. However, ve...

    Authors: Dereje Assefa Geleta, Yoseph Cherinet Megerssa, Adugna Negussie Gudeta, Gizachew Taddesse Akalu, Melaku Tesfaye Debele and Kassu Desta Tulu

    Citation: BMC Microbiology 2015 15:220

    Content type: Research article

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  24. Shiga toxin–producing Escherichia coli (STEC) O157:H7 is a well-recognized cause of bloody diarrhea and hemolytic-uremic syndrome (HUS). The ability of STEC strains to cause human disease is due to the production...

    Authors: Benson C. Iweriebor, Chinwe J. Iwu, Larry C. Obi, Uchechukwu U. Nwodo and Anthony I. Okoh

    Citation: BMC Microbiology 2015 15:213

    Content type: Research article

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  25. A significant trend towards increased fusidic acid (FA) resistance among Staphylococcus aureus with increased duration of use is of concern. The aim of the present study is to investigate the dissemination of fus...

    Authors: Fangyou Yu, Yunling Liu, Chaohui Lu, Jinnan LV, Xiuqin Qi, Yu Ding, Dan Li, Xiaoying Huang, Longhua Hu and Liangxing Wang

    Citation: BMC Microbiology 2015 15:210

    Content type: Research article

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  26. In this study we describe the clinical and molecular characteristics of an outbreak due to carbapenem-resistant Klebsiella pneumoniae (CR-KP) producing CTX-M-15 and OXA-48 carbapenemase. Isogenic strains, carbape...

    Authors: Meritxell Cubero, Guillermo Cuervo, M. Ángeles Dominguez, Fe Tubau, Sara Martí, Elena Sevillano, Lucía Gallego, Josefina Ayats, Carmen Peña, Miquel Pujol, Josefina Liñares and Carmen Ardanuy

    Citation: BMC Microbiology 2015 15:177

    Content type: Research article

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  27. Clostridium difficile can cause antibiotic-associated diarrhea and a possibility of outbreaks in hospital settings warrants molecular typing. A microarray was designed that included to...

    Authors: Darius Gawlik, Peter Slickers, Ines Engelmann, Elke Müller, Christian Lück, Anette Friedrichs, Ralf Ehricht and Stefan Monecke

    Citation: BMC Microbiology 2015 15:158

    Content type: Research article

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  28. Staphylococcal toxicity and antibiotic resistance (STAAR) have been menacing public health. Although vancomycin-resistant Staphylococcus aureus (VRSA) is currently not as widespread as methicillin-resistant S. au...

    Authors: Charles Emeka Okolie, Karl G. Wooldridge, David P.J. Turner, Alan Cockayne and Richard James

    Citation: BMC Microbiology 2015 15:157

    Content type: Research article

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  30. To investigate antibiotic resistance, the occurrence and distribution of class 1 and 2 integrons in multidrug- resistant Staphylococcus aureus isolates from hospitals in Tehran, Iran.

    Authors: Mahdi Mostafa, Seyed Davar Siadat, Fereshteh Shahcheraghi, Farzam Vaziri, Alireza Japoni-Nejad, Jalil Vand Yousefi, Bahareh Rajaei, Elnaz Harifi Mood, Nayyereh Ebrahim zadeh, Arfa Moshiri, Seyed Alireza Seyed Siamdoust and Mohamad Rahbar

    Citation: BMC Microbiology 2015 15:152

    Content type: Research article

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  31. Human platelets are a rich reservoir of molecules that promote regenerative processes and microbicidal activity. This activity might be increased by concentration in platelet-rich plasma (PRP) products and mod...

    Authors: Erminia Mariani, Valentina Canella, Andrea Berlingeri, Alessandra Bielli, Luca Cattini, Maria Paola Landini, Elizaveta Kon, Maurilio Marcacci, Berardo Di Matteo and Giuseppe Filardo

    Citation: BMC Microbiology 2015 15:149

    Content type: Research article

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  32. The epidemiology of invasive meningococcal disease (IMD) in Québec, Canada, has been dominated in the past decade by a clone of serogroup B (MenB) Neisseria meningitidis defined by multi-locus sequence typing (ML...

    Authors: Dennis K.S. Law, Brigitte Lefebvre, Rodica Gilca, Saul Deng, Jianwei Zhou, Philippe De Wals and Raymond S.W. Tsang

    Citation: BMC Microbiology 2015 15:143

    Content type: Research article

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  33. The sexually transmitted infection gonorrhea remains a public health concern for becoming resistant to drug treatments available. The purpose of this study was to evaluate the usefulness of the matrix-assisted...

    Authors: Anna Carannante, Elena De Carolis, Paola Vacca, Antonietta Vella, Caterina Vocale, Maria Antonia De Francesco, Marco Cusini, Simonetta Del Re, Ivano Dal Conte, Antonio Cristaudo, Patrizia Ober, Maurizio Sanguinetti and Paola Stefanelli

    Citation: BMC Microbiology 2015 15:142

    Content type: Research article

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  34. Circulating enterovirus 71 (EV-A71)-associated hand, foot, and mouth disease is on the rise in the Asian-Pacific region. Although animal models have been developed using mouse-adapted EV-A71 strains, mouse mod...

    Authors: Junliang Chang, Jingliang Li, Xin Liu, Guanchen Liu, Jiaxin Yang, Wei Wei, Wenyan Zhang and Xiao-Fang Yu

    Citation: BMC Microbiology 2015 15:139

    Content type: Research article

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  36. Infections by Pseudomonas aeruginosa constitute a serious health threat because this pathogen –particularly when it forms biofilms – can acquire resistance to the majority of conventional antibiotics. This study ...

    Authors: Susana Sánchez-Gómez, Raquel Ferrer-Espada, Philip S. Stewart, Betsey Pitts, Karl Lohner and Guillermo Martínez de Tejada

    Citation: BMC Microbiology 2015 15:137

    Content type: Research article

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  37. Salmonella enterica spp. enterica serotype Typhimurium (STM) is the most common agent of domestically acquired salmonellosis in Finland. Subtyping methods which allow the characterization of ST...

    Authors: Taru Lienemann, Aino Kyyhkynen, Jani Halkilahti, Kaisa Haukka and Anja Siitonen

    Citation: BMC Microbiology 2015 15:131

    Content type: Research article

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  38. The microbiological procedures for cystic fibrosis (CF) samples of 17 participating Spanish centers were examined to verify their compliance with current international and national guidelines and to implement ...

    Authors: Juan de Dios Caballero, Rosa del Campo, Marta Tato, Elia Gómez G de la Pedrosa, Marta Cobo, Carla López-Causapé, Enrique Gómez-Mampaso, Antonio Oliver and Rafael Cantón

    Citation: BMC Microbiology 2014 14:335

    Content type: Research article

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  39. Human T-lymphotropic virus 1 (HTLV-1) has been associated with leukemia/lymphoma (ATL) and myelopathy/tropical spastic paraparesis (HAM/TSP), in addition to other inflammatory diseases as well as infection com...

    Authors: Camila Pacheco Silveira Martins, Orlando Abreu Gomes, Marina Lobato Martins, Luciana Debortoli de Carvalho, Jaqueline Gontijo de Souza, Flavio Guimaraes Da Fonseca, Rodrigo Gonçalves Silva dos Santos, Margareth Spangler Andrade, Carlos Leomar Zani, Elaine Maria de Souza-Fagundes and Edel Figueiredo Barbosa-Stancioli

    Citation: BMC Microbiology 2014 14:331

    Content type: Research article

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  40. Currently, a licensed vaccine for Dengue Virus (DENV) is not yet available. Virus-like particles (VLP) have shown considerable promise for use as vaccines and have many advantages compared to many other types ...

    Authors: Yan Liu, Junmei Zhou, Zhizhun Yu, Danyun Fang, Chunyun Fu, Xun Zhu, Zhenjian He, Huijun Yan and Lifang Jiang

    Citation: BMC Microbiology 2014 14:233

    Content type: Research article

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  41. Lactobacillus represents a large genus with different implications for the human host. Specific lactobacilli are considered to maintain vaginal health and to protect from urogenital infection. The presence of La...

    Authors: Annette Carola Anderson, Mohamed Sanunu, Christian Schneider, Andreas Clad, Lamprini Karygianni, Elmar Hellwig and Ali Al-Ahmad

    Citation: BMC Microbiology 2014 14:312

    Content type: Research article

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  42. Preliminary studies showed the prevalence of a virus similar to human hepatitis B virus (HBV-like) in swine from farms in China and the molecular evidence of Hepadnavirus infection in domestic pigs herds in Br...

    Authors: Yasmine Rangel Vieira, Debora Regina Lopes dos Santos, Moyra Machado Portilho, Carlos Eduardo Pereira Velloso, Marcia Arissawa, Livia Melo Villar, Marcelo Alves Pinto and Vanessa Salete de Paula

    Citation: BMC Microbiology 2014 14:315

    Content type: Research article

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  43. Microbiological diagnosis of sepsis relies primarily on blood culture data. This study compares four diagnostic methods, i.e. those developed by us: nested, multiplex, qPCR (qPCR) and FISH with commercial meth...

    Authors: Tomasz Gosiewski, Agnieszka Flis, Agnieszka Sroka, Anna Kędzierska, Agata Pietrzyk, Jolanta Kędzierska, Rafał Drwiła and Małgorzata Bulanda

    Citation: BMC Microbiology 2014 14:313

    Content type: Methodology article

    Published on:

  44. Papua New Guinea (PNG) is a high tuberculosis (TB) burden country of the WHO Western Pacific Region, but so far research on drug resistance (DR) and genotypes of Mycobacterium tuberculosis (M. tuberculosis) was o...

    Authors: Serej D Ley, Paul Harino, Kilagi Vanuga, Ruben Kamus, Robyn Carter, Christopher Coulter, Sushil Pandey, Julia Feldmann, Marie Ballif, Peter M Siba, Suparat Phuanukoonnon, Sebastien Gagneux and Hans-Peter Beck

    Citation: BMC Microbiology 2014 14:307

    Content type: Research article

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  45. Biofilm formation by Candida albicans has shown to be highly variable and is directly associated with pathogenicity and poor clinical outcomes in patients at risk. The aim of this study was to test the hypotheses...

    Authors: Ranjith Rajendran, Leighann Sherry, David F Lappin, Chris J Nile, Karen Smith, Craig Williams, Carol A Munro and Gordon Ramage

    Citation: BMC Microbiology 2014 14:303

    Content type: Research article

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  46. Biofilm-forming Candida species cause infections that can be difficult to eradicate, possibly because of antifungal drug tolerance mechanisms specific to biofilms. In spite of decades of research, the connection ...

    Authors: Rasmus Bojsen, Birgitte Regenberg and Anders Folkesson

    Citation: BMC Microbiology 2014 14:305

    Content type: Research article

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  47. Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) recently became available for the identification of bacteria in routine diagnostic laboratories. It is rapid and cost...

    Authors: Wafaa Jamal, M John Albert and Vincent O Rotimi

    Citation: BMC Microbiology 2014 14:289

    Content type: Research article

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  48. The hepatitis A virus (HAV) is the most frequent cause of viral hepatitis worldwide and is recognized as one of the most widespread foodborne pathogens. HAV genotypes and subtypes differ in their geographic di...

    Authors: Coralie Coudray-Meunier, Audrey Fraisse, Camélia Mokhtari, Sandra Martin-Latil, Anne-Marie Roque-Afonso and Sylvie Perelle

    Citation: BMC Microbiology 2014 14:296

    Content type: Research article

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  49. Linezolid is one of the most effective treatments against Gram-positive pathogens. However, linezolid-resistant/intermediate strains have recently emerged in worldwide. The purpose of this study was to analyse...

    Authors: Yueru Tian, Tianming Li, Yuanjun Zhu, Bei Wang, Xue Zou and Min Li

    Citation: BMC Microbiology 2014 14:292

    Content type: Research article

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  50. Candida tropicalis is considered to be the leading pathogen causing nosocomial fungemia and hepatosplenic fungal infections in patients with cancer, particularly those with leukemia. Microsatellite-based typing ...

    Authors: Yuan Wu, Hai-jian Zhou, Jie Che, Wen-ge Li, Fu-ning Bian, Shuan-bao Yu, Li-juan Zhang and Jinxing Lu

    Citation: BMC Microbiology 2014 14:245

    Content type: Research article

    Published on:

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