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Clinical microbiology and vaccines

This section aims to publish studies looking at all aspects of clinical microbiology, including virology, epidemiology, antimicrobial resistance, vaccines and immune responses.

Page 8 of 8

  1. Chlamydia trachomatis is an intracellular bacterium that resides in the conjunctival and reproductive tract mucosae and is responsible for an array of acute and chronic diseases. A percentage of these infections ...

    Authors: Cassandra J Wasson, Jessica L Zourelias, Nathan A Aardsma, Janis T Eells, Mike T Ganger, Justine M Schober and Troy A Skwor

    Citation: BMC Microbiology 2012 12:176

    Content type: Research article

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  2. Campylobacter jejuni, the most leading cause for bacterial gastroenteritis worldwide, shows a high genetic diversity among its isolates. Recently, we demonstrated the existence of six C. jejuni-groups by combinin...

    Authors: Andreas E Zautner, Carolin Ohk, Abdul Malik Tareen, Raimond Lugert and Uwe Groß

    Citation: BMC Microbiology 2012 12:171

    Content type: Research article

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  3. Several reports have associated Staphylococcus lugdunensis with the incidence of severe infection in humans; however, the frequency and prevalence of this microorganism and thus the propensity of its antimicrobia...

    Authors: Chaojun Liu, Dingxia Shen, Jing Guo, Kaifei Wang, Huan Wang, Zhongqiang Yan, Rong Chen and Liyan Ye

    Citation: BMC Microbiology 2012 12:168

    Content type: Research article

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  4. Methicillin-resistant Staphylococcus aureus (MRSA) is spreading worldwide and poses a serious public health problem, being present in hospital settings and communities. However, from the Middle East and the Arabi...

    Authors: Stefan Monecke, Leila Skakni, Rami Hasan, Antje Ruppelt, Sameeh S Ghazal, Ahmed Hakawi, Peter Slickers and Ralf Ehricht

    Citation: BMC Microbiology 2012 12:146

    Content type: Research article

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  5. Procalcitonin (PCT) is a polypeptide with several cationic aminoacids in its chemical structure and it is a well known marker of sepsis. It is now emerging that PCT might exhibit some anti-inflammatory effects...

    Authors: Giovanni Matera, Angela Quirino, Aida Giancotti, Maria Concetta Pulicari, Linda Rametti, Maria Luz Rodríguez, Maria Carla Liberto and Alfredo Focà

    Citation: BMC Microbiology 2012 12:68

    Content type: Research article

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  6. Capsular serotypes K1 and K2 of Klebsiella pneumoniae are thought to the major virulence determinants responsible for liver abscess. The intestine is one of the major reservoirs of K. pneumoniae, and epidemiologi...

    Authors: Yi-Tsung Lin, L Kristopher Siu, Jung-Chung Lin, Te-Li Chen, Chih-Peng Tseng, Kuo-Ming Yeh, Feng-Yee Chang and Chang-Phone Fung

    Citation: BMC Microbiology 2012 12:13

    Content type: Research article

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  7. Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansio...

    Authors: Jolene R Bowers, Elizabeth M Driebe, Jennifer L Nibecker, Bette R Wojack, Derek S Sarovich, Ada H Wong, Pius M Brzoska, Nathaniel Hubert, Andrew Knadler, Lindsey M Watson, David M Wagner, Manohar R Furtado, Michael Saubolle, David M Engelthaler and Paul S Keim

    Citation: BMC Microbiology 2012 12:12

    Content type: Research article

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  8. Shigella flexneri is the major pathogen causing bacillary dysentery. Fifteen serotypes have been recognized up to now. The genesis of new S. flexneri serotypes is commonly mediated by serotype-converting bacterio...

    Authors: Qiangzheng Sun, Ruiting Lan, Yiting Wang, Jianping Wang, Xia Luo, Shaomin Zhang, Peijing Li, Yan Wang, Changyun Ye, Huaiqi Jing and Jianguo Xu

    Citation: BMC Microbiology 2011 11:269

    Content type: Research article

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  9. Since 1950, Brucella melitensis has been the predominant strain associated with human brucellosis in China. In this study we investigated the genotypic characteristics of B. melitensis isolates from China using a...

    Authors: Hai Jiang, Mengguang Fan, Jingdiao Chen, Jingchuan Mi, Ruiping Yu, Hongyan Zhao, Dongri Piao, Changwen Ke, Xiaoling Deng, Guozhong Tian and Buyun Cui

    Citation: BMC Microbiology 2011 11:256

    Content type: Research article

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  10. Culture and quantitative polymerase chain reaction (qPCR) assays for the detection of Legionella were compared on samples from a residential area before and after two interventions. A total of 84 samples were col...

    Authors: Louise H Krøjgaard, Karen A Krogfelt, Hans-Jørgen Albrechtsen and Søren A Uldum

    Citation: BMC Microbiology 2011 11:254

    Content type: Research article

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  11. Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) are two major etiological agents of Hand, Foot and Mouth Disease (HFMD). EV71 is associated with severe cases but not CA16. The mechanisms contributed to the...

    Authors: Yuyun Li, Runan Zhu, Yuan Qian, Jie Deng, Yu Sun, Liying Liu, Fang Wang and Linqing Zhao

    Citation: BMC Microbiology 2011 11:246

    Content type: Research article

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  12. Urine within the urinary tract is commonly regarded as "sterile" in cultivation terms. Here, we present a comprehensive in-depth study of bacterial 16S rDNA sequences associated with urine from healthy females...

    Authors: Huma Siddiqui, Alexander J Nederbragt, Karin Lagesen, Stig L Jeansson and Kjetill S Jakobsen

    Citation: BMC Microbiology 2011 11:244

    Content type: Research article

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  13. Antimicrobial resistance mediated by efflux systems is still poorly characterized in Staphylococcus aureus, despite the description of several efflux pumps (EPs) for this bacterium. In this work we used several m...

    Authors: Sofia Santos Costa, Celeste Falcão, Miguel Viveiros, Diana Machado, Marta Martins, José Melo-Cristino, Leonard Amaral and Isabel Couto

    Citation: BMC Microbiology 2011 11:241

    Content type: Research article

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    The Erratum to this article has been published in BMC Microbiology 2013 13:127

  14. Epidemiology of celiac disease (CD) is increasing. CD mainly presents in early childhood with small intestinal villous atrophy and signs of malabsorption. Compared to healthy individuals, CD patients seemed to...

    Authors: Raffaella Di Cagno, Maria De Angelis, Ilaria De Pasquale, Maurice Ndagijimana, Pamela Vernocchi, Patrizia Ricciuti, Francesca Gagliardi, Luca Laghi, Carmine Crecchio, Maria Elisabetta Guerzoni, Marco Gobbetti and Ruggiero Francavilla

    Citation: BMC Microbiology 2011 11:219

    Content type: Research article

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  15. Polymerase chain reaction (PCR) ribotyping is one of the globally accepted techniques for defining epidemic clones of Clostridium difficile and tracing virulence-related strains. However, the ambiguous data gener...

    Authors: Hsiao L Wei, Chun Wei Kao, Sung H Wei, Jason TC Tzen and Chien S Chiou

    Citation: BMC Microbiology 2011 11:217

    Content type: Research article

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  16. During extreme physiological stress, the intestinal tract can be transformed into a harsh environment characterized by regio- spatial alterations in oxygen, pH, and phosphate concentration. When the human inte...

    Authors: Kathleen Romanowski, Alexander Zaborin, Hoylan Fernandez, Valeriy Poroyko, Vesta Valuckaite, Svetlana Gerdes, Donald C Liu, Olga Y Zaborina and John C Alverdy

    Citation: BMC Microbiology 2011 11:212

    Content type: Research article

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  17. H. pylori (Helicobacter pylori) is the major causative agent of chronic active gastritis. The population of H. pylori shows a high genomic variability among isolates. And the polymorphism of repeat-units of genom...

    Authors: Chunliang Guo, Yaling Liao, Yan Li, Jun Duan, Ying Guo, Yuqian Wu, Yujun Cui, Hongwu Sun, Jinyong Zhang, Bing Chen, Quanming Zou and Gang Guo

    Citation: BMC Microbiology 2011 11:197

    Content type: Research article

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  18. Studies have suggested that demographic and lifestyle factors could shape the composition of fecal microbiota in early life. This study evaluated infant stool microbiota signatures in two Asian populations, Si...

    Authors: Gaik Chin Yap, Kok Keong Chee, Pei-Ying Hong, Christophe Lay, Cahya D Satria, Sumadiono, Yati Soenarto, Ekawaty L Haksari, Marion Aw, Lynette Pei-Chi Shek, Kaw Yan Chua, Yudong Zhao, Doreen Leow and Bee Wah Lee

    Citation: BMC Microbiology 2011 11:193

    Content type: Research article

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  19. Antibiotics which inhibit bacterial peptidoglycan biosynthesis are the most widely used in current clinical practice. Nevertheless, resistant strains increase dramatically, with serious economic impact and eff...

    Authors: Rebeca Santiso, María Tamayo, Jaime Gosálvez, Germán Bou, María del Carmen Fernández and José Luis Fernández

    Citation: BMC Microbiology 2011 11:191

    Content type: Methodology article

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  20. Porcine circovirus type 2 (PCV2) is associated with post-weaning multisystemic wasting syndrome (PMWS) in pigs. Currently, there is considerable interest in the immunology of PCV2; in particular, the immunolog...

    Authors: Li P Huang, Yue H Lu, Yan W Wei, Long J Guo and Chang M Liu

    Citation: BMC Microbiology 2011 11:188

    Content type: Research article

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  21. Candida parapsilosis is frequently isolated from hospital environments, like air and surfaces, and causes serious nosocomial infections. Molecular studies provided evidence of great genetic diversity within the C...

    Authors: Raquel Sabino, Paula Sampaio, Catarina Carneiro, Laura Rosado and Célia Pais

    Citation: BMC Microbiology 2011 11:180

    Content type: Research article

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  22. Diarrheal infections caused by Salmonella, are one of the major causes of childhood morbidity and mortality in developing countries. Salmonella causes various diseases that range from mild gastroenteritis to ente...

    Authors: Natalia A Castillo, Gabriela Perdigón and Alejandra de Moreno de LeBlanc

    Citation: BMC Microbiology 2011 11:177

    Content type: Research article

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  23. Specific cell targeting is an important, yet unsolved problem in bacteria-based therapeutic applications, like tumor or gene therapy. Here, we describe the construction of a novel, internalin A and B (InlAB)-d...

    Authors: Martin Heisig, Alexa Frentzen, Birgit Bergmann, Katharina Galmbacher, Ivaylo Gentschev, Christian Hotz, Christoph Schoen, Jochen Stritzker, Joachim Fensterle, Ulf R Rapp and Werner Goebel

    Citation: BMC Microbiology 2011 11:163

    Content type: Research article

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  24. Streptococcus suis is a zoonotic pathogen that causes infections in young piglets. S. suis is a heterogeneous species. Thirty-three different capsular serotypes have been described, that differ in virulence betwe...

    Authors: Astrid de Greeff, Henk J Wisselink, Freddy M de Bree, Constance Schultsz, Christoph G Baums, Hoa Ngo Thi, Norbert Stockhofe-Zurwieden and Hilde E Smith

    Citation: BMC Microbiology 2011 11:161

    Content type: Research article

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  25. Infantile colic is a common disturb within the first 3 months of life, nevertheless the pathogenesis is incompletely understood and treatment remains an open issue. Intestinal gas production is thought to be o...

    Authors: Francesco Savino, Lisa Cordisco, Valentina Tarasco, Emanuela Locatelli, Diana Di Gioia, Roberto Oggero and Diego Matteuzzi

    Citation: BMC Microbiology 2011 11:157

    Content type: Research article

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  26. Rapid identification (ID) and antibiotic susceptibility testing (AST) of the causative micro-organism of bloodstream infections result in earlier targeting of antibiotic therapy.

    Authors: Judith Beuving, Christina FM van der Donk, Catharina FM Linssen, Petra FG Wolffs and Annelies Verbon

    Citation: BMC Microbiology 2011 11:156

    Content type: Research article

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  27. Enterococci are increasingly associated with opportunistic infections in Humans but the role of the oral cavity as a reservoir for this species is unclear. This study aimed to explore the carriage rate of Enteroc...

    Authors: Bochra Kouidhi, Tarek Zmantar, Kacem Mahdouani, Hajer Hentati and Amina Bakhrouf

    Citation: BMC Microbiology 2011 11:155

    Content type: Research article

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  28. Salmonella species are recognized worldwide as a significant cause of human and animal disease. In this study the molecular profiles and characteristics of Salmonella enterica Senftenberg isolated from human case...

    Authors: Ryan M Stepan, Julie S Sherwood, Shana R Petermann and Catherine M Logue

    Citation: BMC Microbiology 2011 11:153

    Content type: Research article

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  29. Many chronic diseases, such as non-healing wounds are characterized by prolonged inflammation and respond poorly to conventional treatment. Bacterial biofilms are a major impediment to wound healing. Persisten...

    Authors: Patrick R Secor, Garth A James, Philip Fleckman, John E Olerud, Kate McInnerney and Philip S Stewart

    Citation: BMC Microbiology 2011 11:143

    Content type: Research article

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  30. V. cholerae is the etiological agent of cholera, a major public health concern in most developing countries. Virulence of V. cholerae relies on the powerful cholera toxin, encoded by the CTX prophage. The emergen...

    Authors: Daniela Ceccarelli, Matteo Spagnoletti, Donatella Bacciu, Piero Cappuccinelli and Mauro M Colombo

    Citation: BMC Microbiology 2011 11:130

    Content type: Research article

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  31. Chronic, infected wounds typically contain multiple genera of bacteria, including Staphylococcus aureus, many of which are strong biofilm formers. Bacterial biofilms are thought to be a direct impediment to wound...

    Authors: Scott N Dean, Barney M Bishop and Monique L van Hoek

    Citation: BMC Microbiology 2011 11:114

    Content type: Research article

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  32. Cystic fibrosis (CF) lung disease has a unique profile of pathogens predominated by Pseudomonas aeruginosa (PsA) and Staphylococcus aureus (SA). These microorganisms must overcome host immune defense to colonize ...

    Authors: Ryan W Bonvillain, Richard G Painter, Elisa M Ledet and Guoshun Wang

    Citation: BMC Microbiology 2011 11:112

    Content type: Research article

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  33. Since 1991 several outbreaks of acute coccidioidomycosis (CM) were diagnosed in the semi-arid Northeast of Brazil, mainly related to disturbance of armadillo burrows caused by hunters while digging them for th...

    Authors: Regina CL de Macêdo, Alexandre S Rosado, Fabio F da Mota, Maria AS Cavalcante, Kelsen D Eulálio, Antônio D Filho, Liline MS Martins, Márcia S Lazéra and Bodo Wanke

    Citation: BMC Microbiology 2011 11:108

    Content type: Research article

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  34. Triple therapy is the gold standard treatment for Helicobacter pylori eradication from the human stomach, but increased resistance to clarithromycin became the main factor of treatment failure. Until now, fastidi...

    Authors: Laura Cerqueira, Ricardo M Fernandes, Rui M Ferreira, Fátima Carneiro, Mário Dinis-Ribeiro, Céu Figueiredo, Charles W Keevil, Nuno F Azevedo and Maria J Vieira

    Citation: BMC Microbiology 2011 11:101

    Content type: Methodology article

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  35. The prevalence of resistance to fusidic acid of methicillin-resistant Staphylococcus aureus (MRSA) was increased each year in a Taiwan hospital. Thirty-four MRSA clinical isolates collected in 2007 and 2008 with ...

    Authors: Chih-Ming Chen, Mei Huang, Huei-Fen Chen, Se-Chin Ke, Chia-Ru Li, Jen-Hsien Wang and Lii-Tzu Wu

    Citation: BMC Microbiology 2011 11:98

    Content type: Research article

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  36. Staphylococcus aureus is an important pathogen causing a wide range of infections in the hospital and community setting. In order to have adequate information for treatment of S. aureus infections, it is crucial ...

    Authors: Adebayo O Shittu, Kenneth Okon, Solayide Adesida, Omotayo Oyedara, Wolfgang Witte, Birgit Strommenger, Franziska Layer and Ulrich Nübel

    Citation: BMC Microbiology 2011 11:92

    Content type: Research article

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  38. The β-lactamase (bla) locus, which confers resistance to penicillins only, may control the transcription of mecA, the central element of methicillin resistance, which is embedded in a polymorphic heterelogous chr...

    Authors: Catarina Milheiriço, Ana Portelinha, Ludwig Krippahl, Hermínia de Lencastre and Duarte C Oliveira

    Citation: BMC Microbiology 2011 11:76

    Content type: Research article

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  39. Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in newborn neonates. Bacteria are believed to be important in the pathogenesis of NEC but bacterial characterization has only been ...

    Authors: Birgitte Smith, Susan Bodé, Bodil L Petersen, Tim K Jensen, Christian Pipper, Julie Kloppenborg, Mette Boyé, Karen A Krogfelt and Lars Mølbak

    Citation: BMC Microbiology 2011 11:73

    Content type: Research article

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  40. The extended 'hygiene hypothesis' suggests that the initial composition of the infant gut microbiota is a key determinant in the development of atopic disease. Several studies have demonstrated that the microb...

    Authors: Carl Vael, Liesbeth Vanheirstraeten, Kristine N Desager and Herman Goossens

    Citation: BMC Microbiology 2011 11:68

    Content type: Research article

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  41. Helicobacter pylori infection is one of the most common infections worldwide and is associated with gastric cancer and peptic ulcer. Bacterial virulence factors such as CagA have been shown to increase the risk o...

    Authors: Sérgio A Batista, Gifone A Rocha, Andreia MC Rocha, Ivan EB Saraiva, Mônica MDA Cabral, Rodrigo C Oliveira and Dulciene MM Queiroz

    Citation: BMC Microbiology 2011 11:61

    Content type: Research article

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  42. Salmonella has been employed to deliver therapeutic molecules against cancer and infectious diseases. As the carrier for target gene(s), the cargo plasmid should be stable in the bacterial vector. Plasmid recombi...

    Authors: Xiangmin Zhang, Soo-Young Wanda, Karen Brenneman, Wei Kong, Xin Zhang, Kenneth Roland and Roy Curtiss III

    Citation: BMC Microbiology 2011 11:31

    Content type: Research article

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